This document announces the Agency's receipt of new chemical submissions under the Toxic Substances Control Act (TSCA), including information about the receipt of a Premanufacture Notice (PMN), Significant New Use Notice (SNUN), Microbial Commercial Activity Notice (MCAN), and an amendment to a previously submitted notice; test information; a biotechnology exemption application; an application for a test marketing exemption (TME); and a notice of commencement of manufacture (defined by statute to include import) (NOC) for a new chemical substance. This document also provides a periodic status report on the new chemical substances that are currently under EPA review or have recently concluded review. EPA is hereby providing notice of receipt of this information, as required by TSCA, and an opportunity to comment. This document covers the period from 9/1/2025 to 9/30/2025.
This document announces the Agency's receipt of new chemical submissions under the Toxic Substances Control Act (TSCA), including information about the receipt of a Premanufacture Notice (PMN), Significant New Use Notice (SNUN), Microbial Commercial Activity Notice (MCAN), and an amendment to a previously submitted notice; test information; a biotechnology exemption application; an application for a test marketing exemption (TME); and a notice of commencement of manufacture (defined by statute to include import) (NOC) for a new chemical substance. This document also provides a periodic status report on the new chemical substances that are currently under EPA review or have recently concluded review. EPA is hereby providing notice of receipt of this information, as required by TSCA, and an opportunity to comment. This document covers the period from 8/1/2025 to 8/31/2025.
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Additionally, if the active substance meets the exclusion criteria, such as being identified as carcinogenic, mutagenic, toxic for reproduction, or ...
EPA has authorized its contractor and subcontractors, General Dynamic Information Technology (GDIT) of Falls Church VA, Comptech Technology of Dayton Ohio, and Gridiron IT Solutions Inc. of Reston VA, to access information which has been submitted to EPA under all sections of the Toxic Substances Control Act (TSCA). Some of the information may be claimed or determined to be Confidential Business Information (CBI).
The European Chemicals Agency (ECHA) has formally recommended that the European Commission add four new substances to the REACH Authorisation ...
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The European Chemicals Agency (ECHA) has recommended that the European Commission add four substances—including the widely used chemical ...
Ad Hoc Working Party on the ECHA Basic Regulation (morning only)
If a substance is added to the list, companies must obtain authorization before the specified deadline to legally sell or use it within the European ...
... melamine, into the REACH Authorisation List. If adopted by the ... 2018China TaiwanToxic and Concerned Chemical Substance Control Act ...
The EPA has submitted an information collection request (ICR), Consolidation of Certain Reporting and Recordkeeping Under Section 8 of the Toxic Substances Control Act (TSCA) (EPA ICR Number 2703.02, OMB Control Number. 2070-0224) for review and approval in accordance with the Paperwork Reduction Act. This is a proposed extension of the ICR, which is currently approved through November 30, 2025. Public comments were previously requested via the Federal Register on May 9, 2025 during a 60-day comment period. This notice allows for an additional 30 days for public comments.
The General Court has partially annulled a decision by the European Chemicals Agency (ECHA), after finding that regulators relied on a major ...
The Environmental Protection Agency (EPA or Agency) is announcing the availability of and seeking public comment on a draft risk evaluation under the Toxic Substances Control Act (TSCA) for 1,2- dichloroethane (CASRN 107-06-2). The purpose of risk evaluations under TSCA is to determine whether a chemical substance presents an unreasonable risk of injury to health or the environment under the conditions of use (COUs), including unreasonable risk to potentially exposed or susceptible subpopulations identified as relevant to the risk evaluation by EPA, and without consideration of costs or non-risk factors. EPA used the best available science to prepare this draft risk evaluation and to preliminarily determine, based on the weight of scientific evidence, that 1,2-dichloroethane poses unreasonable risk to human health and the environment driven primarily by certain COUs analyzed in the draft risk evaluation.
Melamine was listed as a substance of very high concern in 2022 for being potentially carcinogenic, toxic to the urinary tract and the ...
ECHA recommends clamp-down on melamine. Simon Pickstone. 18 Nov ... appeal at the Court of Justice that is still pending. But in a document ...
ECHA launches SME hub. 18th November 2025 ... Follow Us. TwX logo · LinkedIn Logo. Spec Chem Logo White. c/o In2 Publishing Ltd. Unit 2A Oaklands Court.
The AI pilot aims to determine whether artificial intelligence can assist SMEs in fulfilling their chemical compliance duties. Features include AI ...
The Environmental Protection Agency (EPA or Agency) is extending the postponement of the effectiveness of certain regulatory provisions of the final rule entitled "Trichloroethylene (TCE); Regulation Under the Toxic Substances Control Act (TSCA)" for an additional 90 days. Specifically, this postponement applies to the conditions imposed on the uses with TSCA section 6(g) exemptions.
In the Federal Register of September 17, 2025, Environmental Protection Agency (EPA) announced the availability of and sought public comment on a draft risk evaluation under the Toxic Substances Control Act (TSCA) for Octamethylcyclotetrasiloxane (Cyclotetrasiloxane, 2,2,4,4,6,6,8,8-octamethyl-) (D4) (CASRN 556-67-2). The purpose of risk evaluations under TSCA is to determine whether a chemical substance presents an unreasonable risk of injury to health or the environment under the conditions of use (COUs), including unreasonable risk to potentially exposed or susceptible subpopulations identified as relevant to the risk evaluation by EPA, and without consideration of costs or non-risk factors. EPA used the best available science to prepare this draft risk evaluation and to preliminarily determine, based on the weight of scientific evidence, that D4 poses unreasonable risk to health and the environment driven primarily by COUs analyzed in the draft risk evaluation. This document extends the comment period, which was scheduled to end on November 17, 2025, for 15 days.
The Environmental Protection Agency (EPA or Agency) is finalizing an extension to the compliance dates applicable to certain entities subject to the regulation of methylene chloride promulgated under the Toxic Substances Control Act (TSCA). Specifically, EPA is finalizing an 18-month extension of the Workplace Chemical Protection Program (WCPP) and associated recordkeeping compliance dates for industrial or commercial laboratories that are not owned or operated by Federal agencies or contractors acting on behalf of the Federal government. Under this final rule, all non-Federal laboratories will share the same compliance dates with Federal and Federally contracted laboratories. EPA is finalizing an extension of the compliance dates for associated laboratory activities detailed in this final rule to avoid disruption of important functions of non-Federal laboratories such as the use of environmental monitoring methods needed for cleanup sites and wastewater treatment, as well as activities associated with university laboratories or law enforcement laboratories.
The U.S. Environmental Protection Agency (EPA or Agency) is proposing amendments to the Toxic Substances Control Act (TSCA) regulation for reporting and recordkeeping requirements for perfluoroalkyl and polyfluoroalkyl substances (PFAS). As promulgated in October 2023, the regulation requires manufacturers (including importers) of PFAS in any year between 2011-2022 to report certain data to EPA related to exposure and environmental and health effects. EPA is proposing to incorporate certain exemptions and other modifications to the scope of the reporting regulation. These exemptions would maintain important reporting on PFAS, consistent with statutory requirements, while exempting reporting on activities about which manufacturers are least likely to know or reasonably ascertain.
SG 164/25 European Chemicals Agency adds one substance of very high concern to the Candidate List, triggering legal obligations for industry.
On November 5, 2025, the European Chemicals Agency (ECHA) published mapping of PFAS uses, serving as an industry support document for the upcoming ...
November 5, 2025, the European Chemicals Agency (ECHA) officially announced the 35th batch of 1 substance of very concern, bringing the total ...
In a public statement, the International Fragrance Association (IFRA) says it backs efforts to modernize ECHA and streamline chemical assessments.
The New Substance on the REACH SVHC List: DBDPE · What Components Contain Decabromodiphenyl Ethane (DBDPE)? · Who's Affected by DBDPE Restrictions?
The substance has been added to the SVHC list immediately. Suppliers will have to provide a safety sheet and notify ECHA about any products they ...
On October 20, 2025, the European Chemicals Agency (ECHA) announced the addition of 14 new substance testing proposals and invited public comments ...
For nearly 40 years, GlobalChem has been the premier forum for dialogue on chemical regulation, science policy, and innovation. The 2026 conference will deliver timely updates on federal, state, and international chemicals management, with a continued emphasis on the U.S. Environmental Protection Agency’s (EPA) implementation of the Toxic Substances Control Act (TSCA).
EPA is issuing significant new use rules (SNURs) under the Toxic Substances Control Act (TSCA) for certain chemical substances that were the subject of premanufacture notices (PMNs) and are also subject to an Order issued by EPA pursuant to TSCA. The SNURs require persons to notify EPA at least 90 days before commencing the manufacture (defined by statute to include import) or processing of any of these chemical substances for an activity that is designated as a significant new use in the SNUR. The required notification initiates EPA's evaluation of the conditions of that use for that chemical substance. In addition, the manufacture or processing for the significant new use may not commence until EPA has conducted a review of the required notification, made an appropriate determination regarding that notification, and taken such actions as required by that determination.
EPA is proposing significant new use rules (SNURs) under the Toxic Substances Control Act (TSCA) for certain chemical substances that were the subject of premanufacture notices (PMNs) and are also subject to an Order issued by EPA pursuant to TSCA. The SNURs require persons who intend to manufacture (defined by statute to include import) or process any of these chemical substances for an activity that is proposed as a significant new use by this rulemaking to notify EPA at least 90 days before commencing that activity. The required notification initiates EPA's evaluation of the conditions of that use for that chemical substance. In addition, the manufacture or processing for the significant new use may not commence until EPA has conducted a review of the required notification, made an appropriate determination regarding that notification, and taken such actions as required by that determination.
EPA is proposing significant new use rules (SNURs) under the Toxic Substances Control Act (TSCA) for certain chemical substances that were the subject of premanufacture notices (PMNs) and are also subject to an Order issued by EPA pursuant to TSCA. The SNURs require persons who intend to manufacture (defined by statute to include import) or process any of these chemical substances for an activity that is proposed as a significant new use by this rulemaking to notify EPA at least 90 days before commencing that activity. The required notification initiates EPA's evaluation of the conditions of that use for that chemical substance. In addition, the manufacture or processing for the significant new use may not commence until EPA has conducted a review of the required notification, made an appropriate determination regarding that notification, and taken such actions as required by that determination.
EPA is proposing significant new use rules (SNURs) under the Toxic Substances Control Act (TSCA) for certain chemical substances that were the subject of premanufacture notices (PMNs) and are also subject to an Order issued by EPA pursuant to TSCA. The SNURs require persons who intend to manufacture (defined by statute to include import) or process any of these chemical substances for an activity that is proposed as a significant new use by this rulemaking to notify EPA at least 90 days before commencing that activity. The required notification initiates EPA's evaluation of the conditions of that use for that chemical substance. In addition, the manufacture or processing for the significant new use may not commence until EPA has conducted a review of the required notification, made an appropriate determination regarding that notification, and taken such actions as required by that determination.
... substance of very high concern (SVHC) because of its very persistent and very bioaccumulative (vPvB) properties. ECHA states that it plans to add ...
ECHA states that it plans to add the substance to the Candidate List in November 2025. ECHA notes that “[b]esides the regular obligations ...
... ECHA recently released an updated proposal under the EU's chemical regulation. While the original 2023 proposal included two potential regulatory ...
European Chemicals Agency ECHA announces that Member State Committee agreed to identify DBDPE as a substance of very high concern SVHS due to vPvB ...
... (ECHA) based in Helsinki. Nearly all the rubber used for ... chemical substances and staying within specific limits applicable to each substance.
... Chemical Agency (ECHA), many in Bengaluru and the country at large might be worried, concerned about the claim. However, experts said that there ...
... the European Chemical Agency (ECHA), Indian medical experts have clarified that ethanol use in the country poses no immediate health risk.
ECHA Basic Regulation: Follow-up to AHWP ECHA meeting on 28 October 2025 - CALL FOR COMMENTS
EASA certification ensures that these aviation safety standards are met. At the same time EU Chemical regulations ensure that these same chemicals do ...
New rules under the CLP Regulation and fresh substance evaluations affect coatings manufacturers and formulators across Europe. ECHA's latest ...
ECHA Legislations; Occupational Exposure limits (OELs); Emission Limit Values (ELVs); Other chemical legislations. Expand all Collapse all. About.
An internal working group within ECHA had recommended flagging ethanol as a toxic substance that could increase cancer risk.
... substance. This follows concerns ... For now, the chemical remains approved for biocidal use, pending the outcome of ECHA's November review.
Ahead of this morning’s hearing before the U.S. Senate Environment and Public Works (EPW) Subcommittee on Chemical Safety, Waste Management, Environmental Justice, and Regulatory Oversight, the American Chemistry Council (ACC) today reiterates its call for Congress to address the critical need for sustained improvements to the U.S. Environmental Protection Agency’s (EPA) review of chemicals substances under the Toxic Substances Control Act (TSCA).
... substance due to potential links with cancer and reproductive risks. An internal recommendation by a European Chemicals Agency (ECHA) working ...
... (ECHA) fears that this substance is toxic, increases the risk of cancer and causes complications. In this sense, according to information from the ...
According to the report, the European Chemicals Agency (ECHA) flagged ethanol as a potentially toxic substance following an internal recommendation ...
The ECHA flagged ethanol as toxic, with potential cancer and reproductive harm. The European Commission will decide after scientific review ...
... of the working groups within the European Chemicals Agency (ECHA) flagged ethanol as a toxic substance, which increased the risk of cancer...
... substance may pose a higher risk of cancer. ... The ECHA's assessment focuses on the potential carcinogenic and reproductive toxicity of the chemical.
An internal recommendation on Oct. 10 by one of the working groups within the European Chemicals Agency (ECHA) flagged ethanol as a toxic substance ...
The European Chemicals Agency (ECHA) recently identified ethanol as a potential toxic substance that could increase cancer and pregnancy risks. This ...
... (ECHA) flagged ethanol as a toxic substance, which increased the risk of cancer and pregnancy complications, the FT said, and needed to be ...
An internal recommendation on October 10 by one of the working groups within the European Chemicals Agency (ECHA) flagged ethanol as a toxic substance ...
An internal recommendation on Oct 10 by one of the working groups within the European Chemicals Agency (ECHA) flagged ethanol as a toxic substance ...
... (ECHA) flagged ethanol as a toxic substance which increased the risk of cancer and pregnancy complications and needed to be replaced in cleaning ...
The European Chemicals Agency flagged ethanol as a toxic substance ... ECHA said the substance might contribute to pregnancy complications and ...
... (ECHA) flagged ethanol as a toxic substance, stating it may increase the risk of cancer and pregnancy complications.
... (ECHA) published an internal recommendation calling ethanol a toxic substance that increases the risk of cancer and problems during pregnancy. The ...
An internal recommendation on October 10 by one of the European Chemicals Agency (ECHA) working groups flagged ethanol as a toxic substance ...
... (ECHA) labelled ethanol as potentially toxic. The document suggested that the substance “may increase the risk of cancer and pregnancy ...
The ECHA analysis dwells on the possibility of the chemical to be cancer causing (carcinogenic) and reproductively toxic. If the scientific ...
The European Chemicals Agency (ECHA) flagged ethanol as a toxic substance, citing increased cancer risks and potential reproductive harm ...
The European Chemicals Agency (ECHA) is considering classifying ethanol, a common hand sanitizer ingredient, as a dangerous substance linked to ...
An internal ECHA recommendation from October 10 identifies ethanol as a toxic substance that increases carcinogenic risks and pregnancy complications.
The European Chemicals Agency (ECHA) is reviewing evidence suggesting ethanol exposure could be linked to cancer and reproductive health issues.
... (ECHA) flagged ethanol as a toxic substance, which increased the risk of cancer and pregnancy complications, the FT said. The report added that ...
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The U.S. Environmental Protection Agency (EPA or Agency) is seeking public comment to inform its reconsideration of the Toxic Substances Control Act (TSCA) risk management rule for carbon tetrachloride (CTC). As promulgated in December 2024, the CTC risk management action addressed the unreasonable risk of injury to health presented by CTC under its conditions of use by requiring various workplace exposure controls for most conditions of use, prohibiting certain industrial and commercial uses, and establishing other requirements. This request for public comment follows the filing of several legal challenges to the rule in 2025, and EPA's determination that the CTC risk management rule under TSCA should be reconsidered through further rulemaking. EPA intends to consider information received in response to this public comment solicitation, and other reasonably available information, to inform the development of any proposed rule to amend the CTC regulation as appropriate.
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REGULATION OF THE EUROPEAN PARLIAMENT AND OF THE COUNCIL AMENDING REGULATION (EU) 2023/956 AS REGARDS SIMPLIFYING AND STRENGTHENING THE CARBON BORDER ADJUSTMENT MECHANISM
“If we take a substance off annex XIV, this substance has to be prohibited… the case is clear.” The Commission asked ECHA to prepare a proposal ...
ECHA Basic Regulation: Follow-up to AHWP ECHA on 3 October: Presidency compromise text - Annexes
ECHA Basic Regulation: Follow-up to AHWP ECHA meeting on 3 October 2025 - CALL FOR COMMENTS
... ECHA to classify certain powder forms of titanium dioxide as a carcinogenic substance. ... chemical substance itself. The ruling of the ECJ. In ...
... toxic and carcinogenic substance chromium VI. A close up of a chrome-plated car wheel. Photo: Bulgnn via Getty Images. Share article on Twitter ...
... substance where compliance issues have been identified. Following ... Just last week, ECHA reported that inspections of 2,500 chemical safety ...
The General Court has dismissed an action by AQ seeking annulment of an ECHA decision granting a third party access to a document containing ...
The U.S. Environmental Protection Agency (EPA, "the Agency") is proposing to amend the procedural framework rule for conducting existing chemical risk evaluations under the Toxic Substances Control Act (TSCA). When conducting an existing chemical risk evaluation under TSCA, EPA must determine whether a chemical substance presents an unreasonable risk of injury to health or the environment, without consideration of costs or non-risk factors, including unreasonable risk to a potentially exposed or susceptible subpopulation identified as relevant to the risk evaluation, under the conditions of use. In this action, EPA proposes to rescind or revise certain 2024 amendments to the procedural framework rule to effectuate the best reading of the statute and ensure that the procedural framework rule does not impede the timely completion of risk evaluations or impair the effective and efficient protection of health and the environment.
Chemical Identity and Regulatory Status – For all substances identified, information on chemical identity, physical state, hazard profile ...
The American Chemistry Council (ACC) today issued the following statement in response to the U.S. Environmental Protection Agency’s (EPA) proposed revisions to its risk evaluation framework under the Toxic Substances Control Act (TSCA).
The Environmental Protection Agency (EPA or Agency) is announcing that there will be two virtual public meetings of the Science Advisory Committee on Chemicals (SACC). On November 18, 2025, a preparatory meeting for the SACC to consider the scope and clarity of the draft charge questions for the peer review; and on December 2 through 5, 2025, a peer review meeting for the SACC to consider the octamethylcyclotetrasiloxane (D4) draft risk evaluation, technical support documents, and public comments. EPA is also announcing the availability of and soliciting public comment on the draft documents and charge questions that will be provided to the SACC for this peer review. The draft risk evaluation and technical support documents were prepared under the Toxic Substances Control Act (TSCA) and will be submitted to the SACC for peer review.
Dossier and substance evaluation;. Drinking Water Directive (DWD):. European positive lists (EUPL);. Classification, Labelling and Packaging ...
The Environmental Protection Agency (EPA or Agency) is taking interim final action on the Regulation of Trichloroethylene (TCE) under the Toxic Substances Control Act (TSCA) to revise certain compliance deadlines finalized in 2024. Specifically, EPA is amending the prohibition compliance date for the use of TCE as a processing aid in the manufacture of nuclear fuel, with corresponding changes to the compliance dates for the manufacturing, processing and distribution in commerce of TCE to support such use, to a prohibition on September 15, 2028. EPA is also amending the prohibition compliance date for the disposal of TCE to wastewater by processors of TCE and processors and industrial and commercial users of TCE as a processing aid, to begin on December 18, 2026. EPA is also amending the compliance deadline for downstream notification, and the text required to be present in Safety Data Sheets, to accurately reflect the new prohibition compliance deadline for TCE used as a processing aid in the manufacture of nuclear fuel. EPA is amending this compliance deadline to allow for 90 days after the publication of the final rule for manufacturers, processors, and distributors in commerce of TCE to make such a change. These revisions are necessary to address new information presented to EPA about inadvertent oversights in the original rulemaking and serious concerns that the facilities at issue will be unable to comply with the relevant requirements by the existing deadlines. EPA is requesting comments on all aspects of this interim final rule and will consider all comments received in determining whether amendments to this rule are appropriate after the conclusion of the comment period.
The Environmental Protection Agency (EPA or Agency) is announcing the availability of and seeking public comment on a draft risk evaluation under the Toxic Substances Control Act (TSCA) for Octamethylcyclotetrasiloxane (Cyclotetrasiloxane, 2,2,4,4,6,6,8,8- octamethyl-) (D4) (CASRN 556-67-2). The purpose of risk evaluations under TSCA is to determine whether a chemical substance presents an unreasonable risk of injury to health or the environment under the conditions of use (COUs), including unreasonable risk to potentially exposed or susceptible subpopulations identified as relevant to the risk evaluation by EPA, and without consideration of costs or non-risk factors. EPA used the best available science to prepare this draft risk evaluation and to preliminarily determine, based on the weight of scientific evidence, that D4 poses unreasonable risk to human health and the environment driven primarily by certain conditions of use analyzed in the draft risk evaluation.
The Partnership for Assessment of Risk from Chemicals (PARC) provides a forum for collaboration across Europe between scientists and regulators and aims to pioneer scientific areas addressing most urgent regulatory challenges. In 2023, ECHA published a first map of its key areas of regulatory challenge with the aim to inform and inspire the PARC community developing research of most regulatory relevance. For this 2025 update, we introduced new topics in line with our developing mandate, such as topics to support our future work under the Drinking Water and Water Framework Directive. We also added key topics related to circularity, such as the valuation of chemical-related environmental impacts and releases at the waste stage. In addition, we updated our existing research priorities, particularly in the areas of endocrine disruption, persistence, and the characterisation of polymers. Other topics have received updated status information compared to 2024.