In compliance with the Paperwork Reduction Act (PRA), this document announces that EPA is planning to submit a request to renew and consolidate several existing approved Information Collection Requests (ICRs) to the Office of Management and Budget (OMB). Before submitting the consolidated ICR to OMB for review and approval, EPA is soliciting comments on specific aspects of the proposed information collection that is summarized in this document. The consolidated ICR is titled: "Methylene Chloride; Regulation under TSCA Sec. 6(a)" and identified by EPA ICR No. 2556.04 and OMB Control No. 2070-0204. The ICR and accompanying material are available in the docket for public review and comment.
... industry as regulators not-so-quietly expand the scope of their proposed ban. The European Chemicals Agency (ECHA) publis. An error has occurred ...
The European Chemicals Agency (ECHA) has published the updated proposal ... The fact that a chemical makes a product work does not make it essential.
The European Chemicals Agency (ECHA) on Wednesday expanded its proposal ... chemical safety law, REACH, continues to gather pace. First ...
The European Chemicals Agency (ECHA) has published its updated proposal to restrict per- and polyfluoroalkyl substances (PFAS) in technical textile ...
The Environmental Protection Agency (EPA or Agency) is extending the postponement of the effectiveness of certain regulatory provisions of the final rule entitled "Trichloroethylene (TCE); Regulation Under the Toxic Substances Control Act (TSCA)" for an additional 90 days. Specifically, this postponement applies to the conditions imposed on the uses with TSCA exemptions.
This document announces the Agency's receipt of new chemical submissions under the Toxic Substances Control Act (TSCA), including information about the receipt of a Premanufacture Notice (PMN), Significant New Use Notice (SNUN), Microbial Commercial Activity Notice (MCAN), and an amendment to a previously submitted notice; test information; a biotechnology exemption application; an application for a test marketing exemption (TME); and a notice of commencement of manufacture (defined by statute to include import) (NOC) for a new chemical substance. This document also provides a periodic status report on the new chemical substances that are currently under EPA review or have recently concluded review. EPA is hereby providing notice of receipt of this information, as required by TSCA, and an opportunity to comment. This document covers the period from 5/ 1/2025 to 5/31/2025.
This document announces the Agency's receipt of new chemical submissions under the Toxic Substances Control Act (TSCA), including information about the receipt of a Premanufacture Notice (PMN), Significant New Use Notice (SNUN), Microbial Commercial Activity Notice (MCAN), and an amendment to a previously submitted notice; test information; a biotechnology exemption application; an application for a test marketing exemption (TME); and a notice of commencement of manufacture (defined by statute to include import) (NOC) for a new chemical substance. This document also provides a periodic status report on the new chemical substances that are currently under EPA review or have recently concluded review. EPA is hereby providing notice of receipt of this information, as required by TSCA, and an opportunity to comment. This document covers the period from 6/1/2025 to 6/30/2025.
Three key EU regulations are particularly critical for chemical products: REACH, CLP and the BPR (Biocidal ... The European Chemicals Agency (ECHA) ...
The Toxic Substances Control Act (TSCA) requires EPA to publish in the Federal Register a statement of its findings after its review of certain TSCA submissions when EPA makes a finding that a new chemical substance or significant new use is not likely to present an unreasonable risk of injury to health or the environment. Such statements apply to premanufacture notices (PMNs), microbial commercial activity notices (MCANs), and significant new use notices (SNUNs) submitted to EPA under TSCA. This document presents statements of findings made by EPA on such submissions during the period from June 1, 2025 to June 30, 2025.
... Chemicals Agency (ECHA) proposed classifying TiO2 as a human carcinogen by inhalation. ECHA's Risk Assessment Committee (RAC) adopted an opinion ...
Progress update on the Universal PFAS restriction proposal - The European Chemicals Agency (ECHA) has confirmed that its scientific committees ...
... Chemicals Agency (ECHA) a proposal for classifying TiO₂ as a carcinogen by inhalation under the Classification, Labeling and Packaging (CLP) ...
... Chemicals Agency (ECHA). Action Plan. The EC states that the Action Plan ... This includes simplifying hazardous chemical labeling rules ...
... (ECHA) to classify titanium dioxide as a category 1B carcinogenic substance (carcinogenic to humans). In 2017, ECHA's Committee for Risk Assessment ...
... Chemicals Agency (ECHA). Action Plan. The EC states that the Action Plan proposes the following measures: Resilience and level playing field: The ...
European Commission released a Chemicals Industry Action Plan, simplification omnibus, and ECHA reform proposal to modernize the EU chemical ...
... (ECHA) had failed to take into account all the relevant factors to ... Court's judicial review in cases involving technical and scientific assessments.
The classification was based on a scientific opinion from the European Chemicals Agency (ECHA), which considered that the available scientific ...
... chemical management by requiring companies to register and disclose chemical risks, improving public access to hazard information (ECHA, 2025).
The Environmental Protection Agency (EPA or Agency) is announcing the availability of and seeking public comment on the draft risk evaluations under the Toxic Substances Control Act (TSCA) for Butyl Benzyl Phthalate (BBP) (CARSN 85-68-7) and Diisobutyl Phthalate (DIBP) (CASRN 84-69-5). The purpose of risk evaluations under TSCA is to determine whether a chemical substance presents an unreasonable risk of injury to health or the environment under the conditions of use, including unreasonable risk to potentially exposed or susceptible subpopulations identified as relevant to the risk evaluation by EPA, and without consideration of costs or non-risk factors. EPA used the best available science to prepare this draft risk evaluation and to preliminarily determine, based on the weight of scientific evidence, that BBP and DIBP pose unreasonable risk to health and the environment driven primarily by certain conditions of use analyzed in the draft risk evaluations.
A gap remains in the circular economy conversation: Toxic chemicals in packaging · What should TSCA reform look — and not look — like? This entry ...
... appeals before the Court of Justice. ... That concept is not defined in the Regulation or in ECHA Guidance and is interpreted by ECHA very broadly.
ECHA Will Propose EU-Wide Restrictions On Certain Hexavalent Chromium Substances: The EC requested that the European Chemicals Agency (ECHA) assess ...
The U.S. Environmental Protection Agency (EPA or Agency) is seeking public comment to inform its reconsideration of the Toxic Substances Control Act (TSCA) regulation for perchloroethylene (PCE). As promulgated in December 2024, the PCE risk management action addressed the unreasonable risk of injury to health presented by PCE under its conditions of use by requiring various workplace exposure controls, prohibiting certain industrial and commercial uses, and preventing consumer access to the chemical, among other provisions. This request for public comment follows the filing of several legal challenges to the rule in 2025, and EPA's subsequent determination that the PCE regulation under TSCA should be reconsidered through further rulemaking. EPA intends to consider information received in response to this public comment solicitation, and other reasonably available information, to inform the development of any proposed rule to amend the PCE regulation as appropriate.
ECHA chemicals database for Quaternary ammonium compounds. Benzyl C12 ... Chemical Substances (PACs) under Chemical Substance Control Law (CSCL).
At the 2025 Solutions in Science (SinS) Conference in Brighton, United Kingdom, Suvi Takala, Head of Unit: Chemistry, the European Chemicals ...
EPA is issuing significant new use rules (SNURs) under the Toxic Substances Control Act (TSCA) for certain chemical substances that were the subject of premanufacture notices (PMNs) and a Microbial Commercial Activity Notice (MCAN) and are also subject to an Order issued by EPA pursuant to TSCA. The SNURs require persons to notify EPA at least 90 days before commencing the manufacture (defined by statute to include import) or processing of any of these chemical substances for an activity that is designated as a significant new use in the SNUR. The required notification initiates EPA's evaluation of the conditions of that use for that chemical substance. In addition, the manufacture or processing for the significant new use may not commence until EPA has conducted a review of the required notification; made an appropriate determination regarding that notification; and taken such actions as required by that determination.
... Chemicals Agency (ECHA) Basic Regulation. The CIAP is another cornerstone in the Commission's broader industrial strategy to enhance ...
The European Chemicals Agency (ECHA) has once again updated its Substances of Very High Concern (SVHC) Candidate List. On June 25, 2025, the list ...
The Environmental Protection Agency (EPA or the Agency) is providing notice of its approval of an application for test marketing exemption (TME) under the Toxic Substances Control Act (TSCA). EPA has designated this application as T-24-0001. The test marketing conditions are described in the TME application and in this document.
In 2017, the ECHA told some firms that were registering TFA as a 'high production volume' chemical (to comply with updated European chemicals ...
EPA is making a correction to a final rule that appeared in the Federal Register of June 23, 2025 (FR Doc. 2025-11489). The final rule established significant new use rules (SNURs) under the Toxic Substances Control Act (TSCA) for chemical substances that were the subject of premanufacture notices (PMNs) and Orders issued by EPA pursuant to TSCA.
EPA is making corrections to a final rule that appeared in the Federal Register of June 13, 2025 (FR Doc. 2025-10812). The final rule established significant new use rules (SNURs) under the Toxic Substances Control Act (TSCA) for chemical substances that were the subject of premanufacture notices (PMNs) and Orders issued by EPA pursuant to TSCA.
... Chemicals Agency6 (“ECHA”) to enhance its governance and strengthen its role in legislative processes, among other things. PFAS restriction ...
The court highlighted how the ECHA had concluded that the intrinsic properties of melamine that justified its categorisation on the list of substances ...
EPA is issuing significant new use rules (SNURs) under the Toxic Substances Control Act (TSCA) for certain chemical substances that were the subject of premanufacture notices (PMNs) and are also subject to an Order issued by EPA pursuant to TSCA. The SNURs require persons to notify EPA at least 90 days before commencing the manufacture (defined by statute to include import) or processing of any of these chemical substances for an activity that is designated as a significant new use in the SNUR. The required notification initiates EPA's evaluation of the conditions of that use for that chemical substance. In addition, the manufacture or processing for the significant new use may not commence until EPA has conducted a review of the required notification; made an appropriate determination regarding that notification; and taken such actions as required by that determination.
Ad hoc Working Party on the ECHA Basic Regulation (AHWP ECHA): creation and mandate - Approval
The Toxic Substances Control Act (TSCA) requires EPA to publish in the Federal Register a statement of its findings after its review of certain TSCA submissions when EPA makes a finding that a new chemical substance or significant new use is not likely to present an unreasonable risk of injury to health or the environment. Such statements apply to premanufacture notices (PMNs), microbial commercial activity notices (MCANs), and significant new use notices (SNUNs) submitted to EPA under TSCA. This document presents statements of findings made by EPA on such submissions during the period from May 1, 2025 to May 31, 2025.
... Chemicals Agency (ECHA) via an independent legal framework. The Action ... chemical labelling rules and align information requirements ...
The Helsinki-based European Chemicals Agency (ECHA), which is responsible for the implementation of the EU's main industrial chemicals legislation, is ...
... ECHA. This includes, among other things simplifying hazardous chemical labelling rules, clarifying cosmetics regulations and easing registration ...
ENVI News 14-15 July: 2040 EU climate target, Danish Presidency priorities, hearing of EFSA Executive Director nominee
ENVI News 03 & 07 July 2025: EU-UK Trade and Cooperation Agreement, battery due diligence, marine biodiversity, CBAM, chemicals, biological control agents, Roswall on water resilience strategy
ENVI News 24 June: COP30, climate adaptation, agriculture and sustainable development goals
ENVI News 03-04 June: Executive Director of ECHA, Preparedness Union Strategy, vote on Soil Monitoring and REGI opinion on mid-term review
ENVI News 12-13 May: Exchanges of views with Commissioners Lahbib, Varhelyi and Séjourné, agriculture, protected species and CBAM
ENVI News 23-24 April and 5 May: Climate COP30 preparations, implementation of EU water legislation, PFAS and structured dialogue with Commissioner Hoekstra
ENVI News 7-8 April 2025: Commissioner Roswall, EFSA Director, air quality, eco-design, water resilience, taxonomy and budget
ENVI News 17-18, 19, 20 March 2025: EVP Ribera, EEA Ex. Director, sustainable transport, CBAM, end-of-life vehicles, forests, objections on LIFE programme, SDGs.
ENVI News 17-18 February: Water resilience, end-of-life of vehicles, one-substance-one-assessment, forest monitoring
ENVI News 13, 16 & 23 Jan 2025: Forests, climate adaptation, GMOs&novel food, end of live vehicles, microplastics, Polish Minister Paulina Hennig-Kloska
ENVI News 27-28 January: Water resilience, food controls, climate, cats and dogs
ENVI News 4-5 December 2024: Presentation of EU Agencies' work, Climate reports, Budget Discharges 2023, WHO on Antimicrobial resistance, adoption of negotiation mandates
ENVI News 14 October 2024: Deforestation Regulation & objections to the authorisation of GMOs
ENVI News 04 November 2024: Confirmation Hearings from 4 to 12 November 2024
ENVI News 3 October: NGTs, Clean Transition Dialogues update, Plastic Treaty and CBD COP16
ENVI News 14-15 July: 2040 EU climate target, Danish Presidency priorities, hearing of EFSA Executive Director nominee
ENVI News 23 September: Exchanges of views with the Hungarian Presidency
Source : © European Union, 2025 - EP
ENVI Members will discuss the draft opinion on the 2026 EU Budget, which supports strategic objectives including competitiveness, security, migration, and the green and digital transitions. The Rapporteur highlights the need for coherence between decarbonisation, resilience, and innovation, and calls for continued support to the European Green Deal, including through the Clean Industrial Deal and a water resilience strategy. He also stresses the importance of adequate resources for EEA, ECHA, and EFSA to implement legislation adopted in the previous term, and welcomes the EU's external climate action under the Global Gateway. Members will now submit amendments to the opinion, as well as budgetary amendments, to be voted in ENVI in September and in plenary in October.
Source : © European Union, 2025 - EP
Additionally, the Commission has proposed measures to improve the governance and financial sustainability of the European Chemicals Agency (ECHA).
This document announces the Agency's receipt of new chemical submissions under the Toxic Substances Control Act (TSCA), including information about the receipt of a Premanufacture notice (PMN), Significant New Use Notice (SNUN), Microbial Commercial Activity Notice (MCAN), and an amendment to a previously submitted notice; test information; a biotechnology exemption application; an application for a test marketing exemption (TME); and a notice of commencement of manufacture (defined by statute to include import) (NOC) for a new chemical substance. This document also provides a periodic status report on the new chemical substances that are currently under EPA review or have recently concluded review. EPA is hereby providing notice of receipt of this information, as required by TSCA, and an opportunity to comment. This document covers the period from 4/1/2025 to 4/30/2025.
This document announces the Agency's receipt of new chemical submissions under the Toxic Substances Control Act (TSCA), including information about the receipt of a Premanufacture notice (PMN), Significant New Use Notice (SNUN), Microbial Commercial Activity Notice (MCAN), and an amendment to a previously submitted notice; test information; a biotechnology exemption application; an application for a test marketing exemption (TME); and a notice of commencement of manufacture (defined by statute to include import) (NOC) for a new chemical substance. This document also provides a periodic status report on the new chemical substances that are currently under EPA review or have recently concluded review. EPA is hereby providing notice of receipt of this information, as required by TSCA, and an opportunity to comment. This document covers the period from 2/27/2025 to 3/31/2025.
A science-based proposal, informed by the European Chemicals Agency (ECHA), will be advanced swiftly. Where PFAS are essential and alternatives ...
... substances that can degrade into 'forever chemical' trifluoroacetic acid (TFA). ... 'Forever chemicals': ECHA consults on classifying TFA as reprotoxic.
... substance or mixture classified as hazardous. On advertisement ... 3) Proposal on a Self-Standing European Chemicals Agency (ECHA) Regulation.
European Commission launches Chemicals Industry Package—Action Plan, Sixth Omnibus, and ECHA reform aim to boost competitiveness, simplify rules, ...
The court also dismissed an argument that ECHA should not have been ... substances the European Chemicals Agency is considering adding to its list of ...
... chemicals legislation, alongside a proposal to strengthen the governance and financial sustainability of the European Chemicals Agency (ECHA). - ...
... Court of Justice or the General Court. If the action is well ... ECHA (Melamine) and T-167/23 | LAT Nitrogen Piesteritz and Cornerstone ...
... Chemicals Agency (ECHA) in favour of the identification of melamine as substance of very high concern, namely a chemical substance with probable ...
In the Federal Register of June 20, 2023, EPA proposed significant new use rules (SNURs) under the Toxic Substances Control Act (TSCA) for 18 chemical substances that were the subject of premanufacture notices (PMNs) and a subsequent TSCA Order. EPA is withdrawing the proposed rules because the Agency withdrew the TSCA Order that was the basis of the rules on December 18, 2024.
... Chemicals Agency (ECHA). The Critical Chemical Alliance will identify critical production sites needing policy support and tackle trade issues ...
... chemicals legislation, as well as a proposal to strengthen the governance and financial sustainability of the European Chemicals Agency (ECHA).
... ECHA Basic Regulation” in the third quarter with a stated ambition to enhance the governance and financing of the European Chemicals Agency (ECHA).
The European Chemicals Agency (ECHA) was established in 2007 under the REACH Regulation to handle technical, scientific, and administrative tasks ...
... chemicals legislation, alongside a proposal to strengthen the governance and financial sustainability of the European Chemicals Agency (ECHA). The ...
Tags: Chemicals. Related Articles. Chemicals · ECHA updates timeline for possible chemical restriction proposals. 03 Jul 2024. The European Chemicals ...
... chemical substances, aiming to ensure their safe use throughout their ... ECHA CHEM is ECHA's public chemicals database, launched in early 2024.
The European Centre for Disease Prevention and Control (ECDC), the European Chemicals Agency (ECHA), the European Environment Agency (EEA), the ...
ECHA adds three hazardous chemicals to the Candidate List · Impact of the UK-India FTA on Indian chemical industry · View More · Interviews ...
The European Commission has asked experts at the European Chemical Agency to revisit their assessment of the carcinogenicity of the pesticide ...
Chemicals Agency (ECHA) a dossier supporting the identification of melamine as a substance of very high concern, i.e. a chemical substance ...
ENVI News 03 & 07 July 2025: EU-UK Trade and Cooperation Agreement, battery due diligence, marine biodiversity, CBAM, chemicals, biological control agents, Roswall on water resilience strategy
ENVI News 24 June: COP30, climate adaptation, agriculture and sustainable development goals
ENVI News 03-04 June: Executive Director of ECHA, Preparedness Union Strategy, vote on Soil Monitoring and REGI opinion on mid-term review
ENVI News 12-13 May: Exchanges of views with Commissioners Lahbib, Varhelyi and Séjourné, agriculture, protected species and CBAM
ENVI News 23-24 April and 5 May: Climate COP30 preparations, implementation of EU water legislation, PFAS and structured dialogue with Commissioner Hoekstra
ENVI News 7-8 April 2025: Commissioner Roswall, EFSA Director, air quality, eco-design, water resilience, taxonomy and budget
ENVI News 17-18, 19, 20 March 2025: EVP Ribera, EEA Ex. Director, sustainable transport, CBAM, end-of-life vehicles, forests, objections on LIFE programme, SDGs.
ENVI News 17-18 February: Water resilience, end-of-life of vehicles, one-substance-one-assessment, forest monitoring
ENVI News 13, 16 & 23 Jan 2025: Forests, climate adaptation, GMOs&novel food, end of live vehicles, microplastics, Polish Minister Paulina Hennig-Kloska
ENVI News 27-28 January: Water resilience, food controls, climate, cats and dogs
ENVI News 4-5 December 2024: Presentation of EU Agencies' work, Climate reports, Budget Discharges 2023, WHO on Antimicrobial resistance, adoption of negotiation mandates
ENVI News 14 October 2024: Deforestation Regulation & objections to the authorisation of GMOs
ENVI News 04 November 2024: Confirmation Hearings from 4 to 12 November 2024
ENVI News 3 October: NGTs, Clean Transition Dialogues update, Plastic Treaty and CBD COP16
ENVI News 23 September: Exchanges of views with the Hungarian Presidency
Source : © European Union, 2025 - EP
The European Chemicals Agency (ECHA) has recently added two more substances to its list of chemicals that could potentially harm people or the ...
In compliance with the Paperwork Reduction Act (PRA), this document announces the availability of and solicits public comment on the following Information Collection Request (ICR) that EPA is planning to submit to the Office of Management and Budget (OMB): "Notification of Substantial Risk of Injury to Health and the Environment under TSCA Section 8(e)" (EPA ICR No. 0794.18 and OMB Control No. 2070-0046). This ICR represents a renewal of an existing ICR that is currently approved through April 30, 2026. Before submitting the ICR to OMB for review and approval under the PRA, EPA is soliciting comments on specific aspects of the information collection that is summarized in this document. The ICR and accompanying material are available in the docket for public review and comment.
The European Chemicals Agency (ECHA) has announced the addition of three new substances to its Candidate List of Substances of Very High Concern ...
Reviewing recent developments, Klinger noted that the European Chemicals Agency (ECHA) ... With fluoropolymers widely used in gaskets for their chemical ...
Importers and producers of articles have to notify ECHA if their article contains a Candidate List substance within six months from the date it has ...
Following a decision at the ECHA's member state committee on 16 June, the European Chemicals Agency (ECHA) announced on Wednesday the inclusion in the ...
... Court in Case T-366/22, Ryanair Vs. Commission (Condor II ; COVID ... ECHA adds three hazardous chemicals to the Candidate List - ECHA/NR/25/20 ...
The European Chemicals Agency (ECHA) has added three new hazardous chemicals to its 'Candidate List' of substances of very high concern (SVHCs), ...
... Chemicals Agency (ECHA) said in a statement. A third substance, used in textile treatment products and dyes, was described as toxic for reproduction.
In compliance with the Paperwork Reduction Act (PRA), this document announces the availability of and solicits public comment on the following Information Collection Request (ICR) that EPA is planning to submit to the Office of Management and Budget (OMB): Request for Contractor Access to TSCA Confidential Business Information (CBI) (EPA ICR No. 1250.13 and OMB Control No. 2070-0075). This ICR represents a renewal of an existing ICR that is currently approved through April 30, 2026. Before submitting the ICR to OMB for review and approval under the PRA, EPA is soliciting comments on specific aspects of the information collection that is summarized in this document. The ICR and accompanying material are available in the docket for public review and comment.
ECHA’s achievements in 2024 reflect a strong commitment to our strategic goals and priorities, as well as our vision of chemical safety through science, collaboration and knowledge. We continued to progress and implement our existing legal mandate and also commenced implementation of several new tasks. Our role continues to expand, and in 2024, we supported decision makers as they prepared for the introduction of further new regulatory tasks for the Agency. Throughout the year, we collaborated closely with our many stakeholders, including Member States, the Commission, EU agencies, industry and NGOs. This engagement ensures we can deliver transparent, independent and high-quality scientific opinions and decisions and ensure duty holders meet their legal obligations. While much has been achieved in 2024, the Agency continues to face challenges, which will need to be addressed over the coming period. However, we also took steps to address how the Agency can tackle several of these challenges by modifying our ways or working in the future.
Juliane Glüge researched PFASs at ETH Zurich until the end of May. Until recently, she represented the European Chemical Society in the ECHA committee ...
ENVI News 24 June: COP30, climate adaptation, agriculture and sustainable development goals
ENVI News 03-04 June: Executive Director of ECHA, Preparedness Union Strategy, vote on Soil Monitoring and REGI opinion on mid-term review
ENVI News 12-13 May: Exchanges of views with Commissioners Lahbib, Varhelyi and Séjourné, agriculture, protected species and CBAM
ENVI News 23-24 April and 5 May: Climate COP30 preparations, implementation of EU water legislation, PFAS and structured dialogue with Commissioner Hoekstra
ENVI News 7-8 April 2025: Commissioner Roswall, EFSA Director, air quality, eco-design, water resilience, taxonomy and budget
ENVI News 17-18, 19, 20 March 2025: EVP Ribera, EEA Ex. Director, sustainable transport, CBAM, end-of-life vehicles, forests, objections on LIFE programme, SDGs.
ENVI News 17-18 February: Water resilience, end-of-life of vehicles, one-substance-one-assessment, forest monitoring
ENVI News 13, 16 & 23 Jan 2025: Forests, climate adaptation, GMOs&novel food, end of live vehicles, microplastics, Polish Minister Paulina Hennig-Kloska
ENVI News 27-28 January: Water resilience, food controls, climate, cats and dogs
ENVI News 4-5 December 2024: Presentation of EU Agencies' work, Climate reports, Budget Discharges 2023, WHO on Antimicrobial resistance, adoption of negotiation mandates
ENVI News 14 October 2024: Deforestation Regulation & objections to the authorisation of GMOs
ENVI News 04 November 2024: Confirmation Hearings from 4 to 12 November 2024
ENVI News 3 October: NGTs, Clean Transition Dialogues update, Plastic Treaty and CBD COP16
ENVI News 23 September: Exchanges of views with the Hungarian Presidency
Source : © European Union, 2025 - EP
Comput Toxicol. 2024 Sep 1;31:100327. doi: 10.1016/j.comtox.2024.100327.
ABSTRACT
Per- and Polyfluoroalkyl substances (PFAS) are a class of manufactured chemicals that are in widespread use and many present concerns for persistence, bioaccumulation and toxicity. Whilst a handful of PFAS have been characterized for their hazard profiles, the vast majority have not been extensively studied. Herein, a chemical category approach was developed and applied to PFAS that could be readily characterized by a chemical structure. The PFAS definition as described in the Toxic Substances Control Act (TSCA) section 8(a)(7) rule was applied to the Distributed Structure-Searchable Toxicity (DSSTox) database to retrieve an initial list of 13,054 PFAS. Plausible degradation products from the 563 PFAS on the non-confidential TSCA Inventory were simulated using the Catalogic expert system, and the unique predicted PFAS degradants (2484) that conformed to the same PFAS definition were added to the list resulting in a set of 15,538 PFAS. Each PFAS was then assigned into a primary category using Organisation for Economic Co-operation and Development (OECD) structure-based classifications. The primary categories were subdivided into secondary categories based on a chain length threshold (>=7 vs < 7). Secondary categories were subcategorized using chemical fingerprints to achieve a balance between total number of structural categories vs. level of structural similarity within a category based on the Jaccard index. A set of 128 terminal structural categories were derived from which a subset of representative candidates could be proposed for potential data collection, considering the sparsity of relevant toxicity data within each category, presence on environmental monitoring lists, and the ability to identify plausible manufacturers/importers. Refinements to the approach taking into consideration ways in which the categories could be updated by mechanistic data and physicochemical property information are also described. This categorization approach may be used to form the basis of identifying candidates for data collection with related applications in QSAR development, read-across and hazard assessment.
PMID:40547594 | PMC:PMC12181936 | DOI:10.1016/j.comtox.2024.100327
The Environmental Protection Agency (EPA or Agency) is extending the postponement of the effective date of certain regulatory provisions of the final rule entitled "Trichloroethylene (TCE); Regulation Under the Toxic Substances Control Act (TSCA)" for an additional 60 days. Specifically, this postponement applies to the conditions imposed on the uses with TSCA exemptions.
The Environmental Protection Agency (EPA or Agency) is announcing the availability of the final risk evaluation under the Toxic Substances Control Act (TSCA) for 1,1-dichloroethane (CASRN 75- 34-3). The purpose of risk evaluations under TSCA is to determine whether a chemical substance presents an unreasonable risk of injury to health or the environment under the conditions of use, including unreasonable risk to potentially exposed or susceptible subpopulations identified as relevant to the risk evaluation by EPA, and without consideration of costs or non-risk factors. EPA used the best available science to prepare this final risk evaluation and determined, based on the weight of scientific evidence, that 1,1-dichloroethane presents unreasonable risk to human health driven by three conditions of use because of risks to workers.
The Toxic Substances Control Act (TSCA) requires EPA to publish in the Federal Register a statement of its findings after its review of certain TSCA submissions when EPA makes a finding that a new chemical substance or significant new use is not likely to present an unreasonable risk of injury to health or the environment. Such statements apply to premanufacture notices (PMNs), microbial commercial activity notices (MCANs), and significant new use notices (SNUNs) submitted to EPA under TSCA. This document presents statements of findings made by EPA on such submissions during the period from April 1, 2025 to April 30, 2025.
EPA is issuing significant new use rules (SNURs) under the Toxic Substances Control Act (TSCA) for certain chemical substances that were the subject of premanufacture notices (PMNs) and are also subject to an Order issued by EPA pursuant to TSCA. The SNURs require persons to notify EPA at least 90 days before commencing the manufacture (defined by statute to include import) or processing of any of these chemical substances for an activity that is designated as a significant new use in the SNUR. The required notification initiates EPA's evaluation of the conditions of that use for that chemical substance. In addition, the manufacture or processing for the significant new use may not commence until EPA has conducted a review of the required notification; made an appropriate determination regarding that notification; and taken such actions as required by that determination.
... chemical and certain forms of cancer. Yet, the European Union has extended its ... ECHA, the European authorities for food and chemical safety.
... ECHA" on "various topics related to chemicals." In the fall of 2024, it secured a new advisory contract lasting until 2030. Ramboll also advised ...
It would also empower the European Chemicals Agency (ECHA) to generate data when needed and ensure transparency of scientific studies. Under the ...
The German Federal Environment Agency (UBA) has applied to the European Chemicals Agency (ECHA) for TFA to be classified as toxic for reproduction.
... chemicals, and ensure early detection and action on emerging chemical risks. ... The press release notes that the OSOA package will help ECHA, and other ...
The agreed text includes provisions for situations where the European Chemicals Agency (ECHA) and the European Food Safety Authority (EFSA) reach ...